한국생물물리학회:학술대회논문집 (Proceedings of the Korean Biophysical Society Conference)
- 한국생물물리학회 2001년도 학술 발표회 진행표 및 논문초록
- /
- Pages.20-20
- /
- 2001
Crystal Structure of the PTEN Tumor Suppressor： Implications for Its Phosphoinositide Phosphatase Activity and Membrane Association
- Lee, Jie-Oh (Department of Chemistry, Korea Advanced Institute of Science and Technology) ;
- Haijuan Yang (Memorial Sloan Kettering Cancer Center and Howard Hughes Medical Institut) ;
- Nikola Pavletich (Memorial Sloan Kettering Cancer Center and Howard Hughes Medical Institute)
- 발행 : 2001.06.01
초록
The PTEN tumor suppressor is mutated in diverse human cancers and in hereditary cancer predisposition syndromes. PTEN is a phosphatase that can act on both polypeptide and phosphoinositide substrates in vitro. The PTEN structure reveals a phosphatase domain similar to protein phosphatases but having an enlarged active site important for the accommodation of the phosphoinositide substrate.(omitted)
키워드