Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
- /
- Pages.200-200
- /
- 2001
RETROVIRUS-MEDIATED DELIVERY OF TIMP-2 SUPPRESSES MMP-2 SECRETION AND INVASION: A GENE THERAPY APPROACH
- Ahn, Seong-Min (College of Pharmacy, Duksung Women′s University) ;
- Yeowon Sohn (College of Pharmacy, Duksung Women′s University) ;
- Kim, Yun-Soo (College of Pharmacy, Duksung Women′s University) ;
- Aree Moon (College of Pharmacy, Duksung Women′s University)
- Published : 2001.10.01
Abstract
The matrix metalloproteases (MMPs) play important roles in metastasis and invasion in various cell types. An endogenous inhibitor of MMP, tissue inhibitor of metalloprotease-2 (TIMP-2), has high specificity for MMP-2. An imbalance between MMP-2 and TIMP-2 causes the degradation of the extracellular matrix associated with pathological events including invasion and metastasis. Since TIMPs are secreted molecules, they have the potential to be used for gene therapy of certain tumors. (omitted)
Keywords