한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
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- Pages.186-186
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- 2001
ARYL HYDROCARBON- AND ESTROGEN-MEDIATED SIGNALS POSSIBLY CROSS TALK TO REGULATE CYP1A1 GENE EXPRESSION
- Joung, Ki-Eun (College of pharmacy, Ewha Womans University) ;
- Kim, Yeo-Woon (College of pharmacy, Ewha Womans University) ;
- Min, Kyung-Nan (College of pharmacy, Ewha Womans University) ;
- Sheen, Yhun-Yhong (College of pharmacy, Ewha Womans University)
- 발행 : 2001.10.01
초록
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an environmental toxin that activates the aryl hydrocarbon receptor (AhR) and disrupts multiple endocrine signaling pathways by enhancing ligand metabolism, altering hormone synthesis, down regulating receptor levels, and interfering with gene transcription. And TCDD-mediated gene transactivation via the AhR has been shown to be dependent upon estrogen receptor (ER) expression in human breast cancer cells.(omitted)
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