Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.168-168
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- 2001
FOUR-WEEK INTRAVENOUS TOXICITY EVALUATION OF RECOMBINANT HUMAN ERYTHROPOIETIN, YHB216 IN BEAGLE DOGS
- Sin, Ji-Soon (College of Veterinary Medicine, Chungbuk National University) ;
- Jung, Eun-Yong (College of Veterinary Medicine, Chungbuk National University) ;
- Zhang, Hu-Song (College of Veterinary Medicine, Chungbuk National University) ;
- Huang, Zai-Zhi (College of Veterinary Medicine, Chungbuk National University) ;
- Zheng, Mei-Shu (College of Veterinary Medicine, Chungbuk National University) ;
- Kim, Dong-Kyu (College of Veterinary Medicine, Chungbuk National University) ;
- Roh,Yong-Woo (College of Veterinary Medicine, Chungbuk National University) ;
- Choi, Ehn-Kyung (College of Veterinary Medicine, Chungbuk National University) ;
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Nam, Sang-Yoon
(College of Veterinary Medicine, Chungbuk National University)
;
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Kang, Jong-Koo
(College of Veterinary Medicine, Chungbuk National University)
- Published : 2001.10.01
Abstract
To investigate the safety and toxicity of a recombinant human erythropoietin, YHB216, we performed 4-week repeated dose toxicity test in 4-month-old Beagle dogs. We injected intravenously everyday for 28 days with dosages of 0, 500, 2,500 and 12,500 I.U/kg body weight. There were not observed clinical signs or motality in the animals treated with YHB216. There were no significant changes in body weight, feed, or water consumption.(omitted)
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