한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
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- Pages.157-157
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- 2001
ACTIVATION OF p38 MITOGEN-ACTIVATED PROTEIN KINASE IN H-Ras MCF10A CELLS: ROLE IN H-Ras-INDUCED CELL MOTILITY
- Lee, Eun-Jung (College of Pharmacy, Duksung Womens University) ;
- Kim, Mi-Sung (College of Pharmacy, Duksung Womens University) ;
- Aree Moon (College of Pharmacy, Duksung Womens University)
- 발행 : 2001.10.01
초록
One of the most frequent defects in human cancer is the uncontrolled activation of the ras-signaling pathways. We have previously shown that H-ras, but not N-ras, induces an invasiveness and motility in human breast epithelial cells (MCF10A), while both H-ras and N-ras induce transformed phenotype. Since migration plays a crucial role in invasive, we examined motility of MCF10A cells transformed with H-ras of N-ras.(omitted)
키워드