Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.148-148
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- 2001
EFFECT OF DIFFERENT GENISTEIN CONCENTRATIONS ON EXPRESSION OF $p21^{WAF1}$ , p53, CYCLIN B$_1$ AND BAX; ESTROGEN AGONIST AND ANTAGONIST ACTIONS IN MCF-7 CELLS
- Shin, Jang-In (Applied Sciences, College of Natural Sciences, Hannam University) ;
- Kim, Jung-Hwan (College of Pharmacy, Seoul National University) ;
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Park, Ock-Jin
(Applied Sciences, College of Natural Sciences, Hannam University)
- Published : 2001.10.01
Abstract
Genistein, a phytoestrogen derived from soy isoflavone, has been shown to exert anti-proliferative activities, and have cell arrest and apoptotic effects in cultured tumor cells. However, these properties may not show at the low concentrations of genistein. Present study examined the effect of different concentrations of genistein on cell proliferative proteins, cell cycle regulators or apoptosis related protein in comparison with different concentrations of estrogen or co-treatment with estrogen.(omitted)
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