Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.113-113
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- 2001
COPPER ENHANCEMENT OF L-DOPA-INDUCED OXIDATIVE DNA DAMAGE AND CELL DEATH VIA REDOX CYCLING
- Lee, Jeong-Sang (College of Pharmacy, Seoul National University) ;
- Surh, Young-Joan (College of Pharmacy, Seoul National University)
- Published : 2001.10.01
Abstract
Dopamine, a principal neurotransmitter in the central nervous system, accounts for 90% of total catecholamines. It serves as a precursor of certain hormones, melanins, noradrenalin and adrenalin. Parkinsonian disease (PD) is characterized by selective loss of dopaminergic neurons in the substantia nigra pars compacta and a significant dimunution in the neostriatal content of dopamine and its metabolites.(omitted)
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