Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.31-32
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- 2001
INHIBITION OF CYCLOOXYGENASE-2 AND INDUCIBLE NITRIC OXIDE SYNTHASE BY SELECTED CHEMOPREVENTIVE PHYTOCHEMICALS VIA THE NF-$\textsc{k}$ B SIGNALING PATHWAY
- Surh, Youna-Joon (College of Pharmacy, Seoul National University) ;
- Chun, Kyung-Soo (College of Pharmacy, Seoul National University) ;
- Lee, Ji-Yoon (College of Pharmacy, Seoul National University) ;
- Han, Seong-Su (College of Pharmacy, Seoul National University) ;
- Keum, Young-Sam (College of Pharmacy, Seoul National University) ;
- Seo, Hyo-Joung (College of Pharmacy, Seoul National University) ;
- Lee, Jeong-Hee (College of Pharmacy, Seoul National University) ;
-
Park, Kwang-Kyun
(Yonsei University College of Dentistr)
;
- Lee, Sang-Sup (College of Pharmacy, Seoul National University)
- Published : 2001.10.01
Abstract
A wide array of phenolic substances, particularly those present in dietary and medicinal plants, have been reported to possess substantial anticarcinogenic and antimutagenic activities. The majority of naturally occurring phenolics retain antioxidative and anti-inflammatory properties which appear to contribute to their chemopreventive or chemoprotective activity. Inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) are important enzymes that mediate inflammatory processes.(omitted)
Keywords