Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

ETHENO-DNA ADDUCTS AS OXIDATIVE STRESS-MARKERS IN CANCER ETIOLOGY AND CHEMOPREVENTION STUDIES

  • Bartsch, H. (Division of Toxicology and Cancer Risk Factors, German Cancer Research Center (DKFZ)) ;
  • Nair, J. (Division of Toxicology and Cancer Risk Factors, German Cancer Research Center (DKFZ) ;
  • Owen, R. (Division of Toxicology and Cancer Risk Factors, German Cancer Research Center (DKFZ))
  • Published : 2001.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

Persistent cellular oxidative stress and enhanced lipid peroxidation (LPO) of PUFAs, leading to macromolecular damage and disruption of signaling pathways, are implicated in the development of human malignancies and other chronic degenerative diseases. LPO generates by oxidation of linoleic acid (LA) or arachidonic acid ($\omega$ -6 PUPAs) reactive aldehydes, such as trans-4-hydroxy-2-nonenal, which form etheno $\varepsilon$ -DNA adducts in a variety of human tissues and thus can contribute to diet-related cancers.(omitted)

Keywords