Involvement of p38 mitogen-activated protein kinase in H-ras-induced invasive phenotype and motility

  • Lee, Eun-Jung (Collage of Pharmacy, Duksung Women′s University) ;
  • Kim, Mi-Sung (Collage of Pharmacy, Duksung Women′s University) ;
  • Aree Moon (Collage of Pharmacy, Duksung Women′s University)
  • Published : 2001.05.01

Abstract

One of the most frequent defects in human cancer is the uncontroled activation of the ras-signaling pathway. We have previously shown that H-rasm but not N-ras, induces an invasiveness. Here, we show that cell motility was greatly increased by H-ras, but not by N-ras, suggesting that H-ras-induced invasive phnotype involves enhanced cell motility.(omitted)

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