ACTIVATION OF NF-$\textsc{k}$B AND INDUCTION OF CYCLOOXYGENASE-2 BY NITRIC OXIDE IN MOUSE SKIN

  • 발행 : 2001.05.01

초록

Nitric oxide (NO) has multifaceted roles in carcinogenesis. Besides acting as an initiator, NO may also playa role in the promotional stage of tumorigenesis or neoplastic transformation. In line with this notion, our previous studies have revealed that the tumor promotor phorbol ester induces expression of inducible nitric oxide synthase (iNOS) and NO production in mouse skin.(omitted)

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