CHEMOPREVENTIVE EFFECTS OF XANTHORRHIZOL

  • Park, Kwang-Kyun (Department of Oral Biology, Oral Science Research Center and Brain Korea 21 for Medical Sciences, Yonsei University College of Dentistry) ;
  • Chung, Won-Yoon (Department of Oral Biology, Oral Science Research Center and Brain Korea 21 for Medical Sciences, Yonsei University College of Dentistry) ;
  • Kim, Hee-Ok (Department of Oral Biology, Oral Science Research Center and Brain Korea 21 for Medical Sciences, Yonsei University College of Dentistry) ;
  • Kim, Hee-Kyong (Department of Oral Biology, Oral Science Research Center and Brain Korea 21 for Medical Sciences, Yonsei University College of Dentistry) ;
  • Park, Min-Ah (Department of Oral Biology, Oral Science Research Center and Brain Korea 21 for Medical Sciences, Yonsei University College of Dentistry) ;
  • Kim, Mi-Jeong (Department of Oral Biology, Oral Science Research Center and Brain Korea 21 for Medical Sciences, Yonsei University College of Dentistry) ;
  • Sohn, Joon-Hyung (Department of Oral Biology, Oral Science Research Center and Brain Korea 21 for Medical Sciences, Yonsei University College of Dentistry)
  • Published : 2001.05.01

Abstract

Xanthorrhizol is a sesquiterpenoid isolated from Curcuma xanthorrhiza Roxb. (Zingiberaceae) that has been traditionally used in Indonesia for dietary and medicinal purposes. In our studies to evaluate the cancer chemopreventive potential, xanthorrhizol inhibited the mutagenesis induced by reactive oxygen species in Sa;monella typhimurium TA 102 in a dose-related manner and decreased significantly the incidence and the multiplicity of skin tumors initiated by 7, 12-dimethylbenz[$\alpha$]anthracene and promoted by 12-Ο-tetradecanoylphorbol-13-acetate at 19 weeks.(omitted)

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