Roles of ERK1/2 and p38 Mitogen-Activated Protein Kinases in Phorbol Ester-induced NF-$textsc{k}$B Activation and COX-2 Expression in the Human Breast Epithelial Cell Line (MCF10A)

Inappropriate up-regulation of cyclooxygenase-2 (COX-2) has been implicated for pathogenesis of various types of human cancer. COX-2 expression is known to be regulated by the eukaryotic transcription factor NF-$textsc{k}$B. In an attempt to link the NF-$textsc{k}$B activation and COX-2 induction, we have examined the kinetics of phorbol ester-induced activation of NF-$textsc{k}$B and COX-2 expression in the immortalized human breast epithelial cell line (MCF10A).(omitted)