Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Aryl Hydrocarbon Receptor (AhR) -dependent Inhibition of AP-1 DNA binding by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in LPS-activated B cells

  • Jaehong Suh (Department of Biological Sciences, Korea Advanced Institute of Science and Technology) ;
  • Jeon, Young-Jin (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Hwan-Mook (Korea Research Institute of Bioscience and Biotechnology) ;
  • Norbert E. Kaminski (Department of Pharmacology and Toxicology, Michigan State University) ;
  • Yang, Kyu-Hwan (Department of Biological Sciences, Korea Advanced Institute of Science and Technology)
  • Published : 2001.05.01
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Abstract

B cell has been identified as the sensitive cellular target responsible for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) -induced immune suppression. In isolated cell systems, the differentiation of B cells into antibody secreting plasma cells is believed to be inhibited by TCDD. We also have previously demonstrated IgM secretion was suppressed by TCDD in LPS-activated murine B cell line, CH12.LX.(omitted)

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