Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.05a
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- Pages.94-95
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- 2001
Role of NF-kB in the promotion of hepatocarcinogenesis by chemicals
- Howard P. Glauert (University of Kentucky) ;
- Mason, Karen-Calfee (University of Kentucky) ;
- Yixin Li (University of Kentucky) ;
- Zijing Lu (University of Kentucky) ;
- Vani Nilakantan (University of Kentucky) ;
- Job Tharappel (University of Kentuck) ;
- Larry W. Robertson (University of Kentucky) ;
- Brett T. Spear (University of Kentucky)
- Published : 2001.05.01
Abstract
The purpose of these studies was to determine if hepatic tumor promoters could activate the transcription factor NF-kB, the mechanism of this activation, and whether activation of NF-kB is important in the carcinogenic process. We first demonstrated that the administration of the peroxisome proliferator ciprofibrate increases the hepatic DNA binding activity of NF-kB in rats and mice.(omitted)
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