Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.05a
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- Pages.41-83
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- 2001
The MEK Inhibitor, PD98059 Blocks the Transactivation, but not the Stabilization or DNA Binding Ability, of Hypoxia-Inducible Factor-1$\alpha$
- Hur, Eun-Seon (Department of Life Science, University of Seoul) ;
- Chang, Keun-Young (Department of Life Science, University of Seoul) ;
- Lee, Eun-Jung (College of Pharmacy, Seoul National University) ;
- Lee, Seung-Ki (College of Pharmacy, Seoul National University) ;
- Park, Hyun-Sung (Department of Life Science, University of Seoul)
- Published : 2001.05.01
Abstract
Under low oxygen tension, cells increase the transcription of specific genes that are involved in angiogenesis, erythropoiesis and glycolysis. Hypoxia-induced gene expression primarily depends on the stabilization of the subunit of Hypoxia-Inducible Factor-1 (HIF-1), which acts as a heterodimeric transactivator.(omitted)
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