Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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PROSTAGLANDINS AND THE REGULATION OF TUMOUR CELL GROWTH

  • Bailey, David-Bishop (Department of Cardiac, Vascular ＆ Inflammation Research, William Harvey Research Institute, Charterhouse Square, Queen Mary′s University) ;
  • Jane A. Mitchell (Unit of Critical Care Medicine, Royal Brompton Hospital)
  • Published : 2001.05.01
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Abstract

Increased expression of inducible cyclo-oxygenase (COX-2) is associated with a wide variety of tumours. In addition inhibitors of COX have shown a great deal of promise in vitro and in animal models as potential anti-tumour therapies. COX enzymes utilise the substrate arachidonic acid to produce prostaglandin (PO)H$_2$, the precursor to all the prostanoids.(omitted)

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