Proceedings of the KACD Conference (대한치과보존학회:학술대회논문집)

The Korean Academy of Conservative Dentistry (대한치과보존학회)
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IL-l and $TNF-{\alpha}$ release in human polymorphonuclear leukocytes after exposure to P. endodontalis LPS

  • Park, Chan-Je (Department of Conservative Dentistry, College of Dentistry, Seoul National University) ;
  • Lim, Sung-Sam (Department of Conservative Dentistry, College of Dentistry, Seoul National University)
  • Published : 2001.11.01
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Abstract

Bacterial lipopolysaccharide (LPS) plays a major role in the development of periapical bone resorption. IL-1 and $TNF-{\alpha}$ are known to stimulate bone resorption and inhibit bone formation. Recent evidence has indicated that polymorphonuclear leukocytes (PMNs) have the ability to release IL-1 and $TNF-{\alpha}$ Calcium hydroxide is an effective medicament in root canal infections, reducing the microbial titre within the canal. It has been proposed that the therapeutic effect of $Ca(OH)_2$ may also be the result of direct inactivation of LPS.(omitted)

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