한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)

한국응용약물학회 (The Korean Society of Applied Pharmacology)
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Loxoprofen Sodium의 근육투여시 소염, 진통 및 해열작용

The Anti-inflammatory, Analgesic and Antipyretic Actions of Loxoprofen Sodium in Intramuscular Administration in Rats and Mice

  • Hyun, Jin-Ee (Natural Products Research Institute, Seoul National University) ;
  • Li, Da-Wei (Natural Products Research Institute, Seoul National University) ;
  • Kim, Eun-Young (Natural Products Research Institute, Seoul National University) ;
  • Lee, Eun-Bang (Natural Products Research Institute, Seoul National University) ;
  • Jeong, Choon-Sik (College of Pharmacy, Duksung Women′s University)
  • 발행 : 2001.11.01
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초록

Loxoprofen sodium is an orally used anti-inflammatory, analgesic and antipyretic agent. For alleviation or inhibition of the pain symptoms regardless of referred or superficial pain, the prompt absorption of a drug and its immediate bioavailability might be generally required for a formulation or development of a new drug. Therefore, in intramuscular administration, its anti-inflammatory, analgesic, and antipyretic effects were evaluated compared with an oral administration in animals. The occurrence of gastric damages which is common in nonsteroidal anti-inflammatory drugs was also observed.

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