Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)
- 2001.11a
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- Pages.82-82
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- 2001
Effects of Sophoraflavanone G, a Prenylated Flavonoid from Sophora Flavescens, on Cyclooxygenase-2 and In Vivo Inflammatory Response
- Kim, Dong-Wok (College of Pharmacy, Kangwon National University) ;
- Chi, Yeon-Sook (College of Pharmacy, Kangwon National University) ;
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Son, Kun-Ho
(Dept. Food Nutri., Andong National University) ;
- Chang, Hyeun-Wook (College of Pharmacy, Yeungnam University) ;
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Kim, Ju-Sun
(Natural Products Res, Inst., Seoul National University) ;
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Kang, Sam-Sik
(Natural Products Res, Inst., Seoul National University) ;
- Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University)
- Published : 2001.11.01
Abstract
Previously, several prenylated flavonoids having a C-8 lavandulyl moiety were found to inhibit cyclooxygenase-1 (COX-1) as well as 5-lipoxygenase (5-LOX), and sophoraflavanone G was the most potent inhibitor against these eicosanoid generating enzymes among the prenylated flavonoids tested. In this investigation, effects of sophoraflavanone G on COX-2 induction from RAW 264.7 cells and in vivo inflammatory response were studied. Sophoraflavanone G inhibited prostaglandin E
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