한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 2001년도 추계학술대회 및 정기총회
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- Pages.80-80
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- 2001
Synthesis and Biological Activites of Wogonin
- Jinhyun-Jeong (College of pharmacy, Kyunghee University) ;
- Kim, Dongmyung- (College of pharmacy, Kyunghee University)
- 발행 : 2001.11.01
초록
The roots of Scutellaria baicalensis Georgi have been used in the chinese medicine for the treatment of inflammation, fever and headache. Recent studies had shown that baicalin and baicalein showed a detoxifying effect and could inhibit peripheral capillary permeability, and Wogonin was found to inhibit the proliferation of tumor cells. Wogonin has been synthesized as shown in schem. Compound 2 was prepared from 2,6-dimethoxy-1,4-benzoquinone(1) followed by acylation to give compound 3. The base treatment of 3 gave cyclized product which was carried by deprotection of methyl group chemoselectively. Overall step included relatively simple ten steps.
키워드