한국근적외분광분석학회:학술대회논문집 (Proceedings of the Korean Society of Near Infrared Spectroscopy Conference)
- 한국근적외분광분석학회 2001년도 NIR-2001
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- Pages.4112-4112
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- 2001
CHALLENGING APPLICATIONS FOR FT-NIR SPECTROSCOPY
- Goode, Jon G. (Bruker Optics) ;
- Londhe, Sameer (Bruker Optics) ;
- Dejesus, Steve (Bruker Optics) ;
- Wang, Qian (Bruker Optics)
- 발행 : 2001.06.01
초록
The feasibility of NIR spectroscopy as a quick and nondestructive method for quality control of uniformity of coating thickness of pharmaceutical tablets was investigated. Near infrared spectra of a set of pharmaceutical tablets with varying coating thickness were measured with a diffuse reflectance fiber optic probe connected to a Broker IFS 28/N FT-NIR spectrometer. The challenging issues encountered in this study included: 1. The similarity of the formulation of the core and coating materials, 2. The lack of sufficient calibration samples and 3. The non-linear relationship between the NIR spectral intensity and coating: thickness. A peak at 7184
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