한국전산유체공학회:학술대회논문집

Korean Society of Computational Fluids Engineering (한국전산유체공학회)
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Computational analysis of the hemodynamic changes in human cardiovascular system after space flight

우주비행 직후 인체 심혈관계의 혈류역학적 변화에 대한 수치적 연구

  • Shim E. B. ;
  • Ko H. J. ;
  • Heldt T. ;
  • Kamm R. D. (MIT, Mechanical Eng. & Bioengineering, Mass. Ave. 77, Cambridge 02139, MA, USA) ;
  • Mark R. G. (Harvard-MIT, Gealth Science and Technology, Mass. Ave. 77, Cambridge 02139, MA, USA)
  • 심은보 (금오공과대학교 기계공학과) ;
  • 고형종 (금오공과대학교 기계공학과) ;
  • ;
  • ;
  • Published : 2000.10.01
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Abstract

Orthostatic stress in human cardiovascular system following spaceflight remains a critical problem in the current lifercience space program. The study presented in this paper is part of an ongoing effort to use mathematical models to investigate the effects of gravitational stresses on the cardiovascular system of normals and microgravity adapted individuals. We employ a twelve compartment lumped parameter representation of the hemodynamic system coupled to set-point models of the arterial baroreflex and the cardiopulmonary reflex to investigate the transient response of heart rate to orthostatic stress. We simulate current hypotheses concerning the mechanisms underlying postspaceflight orthostatic intolerance over a range of physiologically reasonable values and compare the simulations to astronaut stand-test data pre-and postflight.

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