Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Blockade of the HERG Human Cardiac $K^+$ Channel by the Antidepressant Drug Amitriptyline

  • Jo, Su-Hyun (Department of Life Science, Pohang University of Science and Technology) ;
  • Lee, Chin. O. (Department of Life Science, Pohang University of Science and Technolog) ;
  • Yung E. Earm (Department of Physiology, Seoul National University College of Medicin) ;
  • Ho, Won-Kyung (Department of Physiology, Seoul National University College of Medicine)
  • Published : 1999.06.01
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Abstract

Amitriptyline has been known to induce QT prolongation and ventricular arrhythmias such as torsades de pointes which causes sudden death. We studied the effects of amitriptyline on the human ether-a-go-go-related gene (HERG) channel expressed in Xenopus oocytes.(omitted)

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