ATP Modulation of Cloned Rat Brain Large-conductance $Ca^{2+}$-activated $K^+$ Channel by Protein Phosphorylation

  • Park, S.Y. (Department of Physiology, College of Medicine, Chung-Ang Univ.) ;
  • S. Chung (Department of Physiology, College of Medicine, Chung-Ang Univ.)
  • Published : 1999.06.01

Abstract

Large conductance $Ca^{2+}$-activated $K^{+}$ channels (Maxi-K channel) have been implicated in many important physiological processes such as co-ordination of membrane excitability in neurons. Modulation of these channels are archived by the activity of various protein kinases. The most widely studied example of Maxi-K channel regulation by protein phosphorylation has been obtained using plasma membranes from the rat brain incorporated into lipid bilayers.(omitted)

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