Effect of Angiotensin II on Synaptic Transmission in the Rat Subfonical Organ

  • Lee, Ho-Sung (Dept. of Pharmacol., Coll. of Vet. Med., Seoul Nat′l Univ.) ;
  • Han, Seong-Kyu (Dept. of Pharmacol., Coll. of Vet. Med., Seoul Nat′l Univ) ;
  • Ryu, Pan-Dong (Dept. of Pharmacol., Coll. of Vet. Med., Seoul Nat′l Univ.)
  • Published : 1999.06.01

Abstract

Circulating substances can directly access the neurons in circumventricular organ (CVO) located on the border of cerebral ventricles. The neurons in CVO are considered to playa pivotal role in blood-brain communication. In subfonical organ (SFO), a CVO in forebrain, angiotensin II (AII) is mown to reduce A type $K^{+}$ current and input resistance, but enhance firing rate.(omitted)

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