한국생물물리학회:학술대회논문집 (Proceedings of the Korean Biophysical Society Conference)

한국생물물리학회 (The Korean Biophysical Society)
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Effect of External Cations on the Voltage-dependent Inactivation of the Rapidly Activating Delayed Rectifier $K^+$ currents $(l_{Kr}$ and HERG Currents

  • Youm, Jae-Boum (Department of Physiology and Heart Research Institute, Seoul National University College of Medicine) ;
  • Jo, Su-Hyun (Department of Life Science, Pohang University of Science and Technolog) ;
  • Ho, Won-Kyung (Department of Physiology and Heart Research Institute, Seoul National University College of Medicin) ;
  • Earm, Yung-E (Department of Physiology and Heart Research Institute, Seoul National University College of Medicine)
  • 발행 : 1999.06.01
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초록

It is well known that rapidly activating delayed rectifier $K^{＋}$ channels ( $I_{Kr}$ ) playa role in repolarisation in mammalian hearts. Recently, human ether-a- go- go related gene (HERG) channels was shown to be a molecular equivalent to $I_{Kr}$ . We have investigated the permeation of various external cations on $I_{Kr}$ in mammalian hearts and on HERG channels expressed in Xenopus laevis oocytes.(omitted)

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