Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Effects of Recombinant Imperatoxin A $(IpTx_a$ mutants on $Ca^{2+}$ Release Channel/Ryanodine Receptor in Rabbit Skeletal Sarcoplasmic Reticulum

  • Seo, In-Ra (Department of Life Science, Kwangju Institute of Science ＆ Technology (K-JIST)) ;
  • Park, Murim (Department of Life Science, Kwangju Institute of Science ＆ Technology (K-JIST) ;
  • Kim, Do-Han (Department of Life Science, Kwangju Institute of Science ＆ Technology (K-JIST))
  • Published : 1999.06.01
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Abstract

Imperatoxin A (IpTx$_{a}$), a 3.7 kDa peptide from the African scorpion Pandinus imperator, has been known as an agonist of skeletal ryanodine receptor (RyR). In order to study the structure and function of the toxins on RyR, the IpTx$_{a}$ cDNA was PCR-amplified using 3 pairs of primers and the toxin was expressed in E. coli expression system.(omitted)ted)

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