Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
권호 표지

Distribution and Structural Basis of the Native Strain in Human $\alpha_1$-Antitrypsin

  • Seo, Eun-Joo (National Creative Research Initiative Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Hana Im (National Creative Research Initiative Center, Korea Research Institute of Bioscience and Biotechnolog) ;
  • Maeng, Jin-Soo (National Creative Research Initiative Center, Korea Research Institute of Bioscience and Biotechnolog) ;
  • Kim, Kyoon-Eon (Dept. of Biochemistry, Chungnam National University) ;
  • Yu, Myeong-Hee (National Creative Research Initiative Center, Korea Research Institute of Bioscience and Biotechnology)
  • Published : 1999.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Metastability in the native form of proteins has been recognized as a mechanism of biological regulation. The strained native structure of serpins (serine proteinase inhibitors) is a typical example. The native strain of serpins is considered to be crucial to their physiological functions, such as plasma proteinase inhibition, hormone delivery, Alzheimer filament assembly, and extracellular matrix remodeling.(omitted)

Keywords