Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)
- 1999.06a
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- Pages.34-34
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- 1999
Crystal Structure of Human TRAIL, the First Molecule With Selective Antitumor Activity
- Cha, Sun-Shin (Department of Life Science, and School of Environmental Engineering, Pohang University of Science and Technology) ;
- Shin, Hang-Cheol (Hanhyo Institute of Science and Technolog) ;
- Oh, Byung-Ha (Department of Life Science, and School of Environmental Engineering, Pohang University of Science and Technology)
- Published : 1999.06.01
Abstract
TRAIL (also known as Apo-2L) is a newly identified cytokine belonging to the large tumor necrosis factor (TNF) family. TRAIL is a novel molecule in that it induces apoptosis in a wide variety of tumor cells but not in normal cells. In order to help elucidating its biological roles and designing mutants with improved therapeutic potential, we have determined the crystal structure of human TRAIL.(omitted)
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