Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Capsaicin Inhibits Phospholipase C-coupled Signaling via the Capacitative $Ca^{2+}$ Entry in PC12 Cells

  • Park, Se-Young (Department of Life Science, Pohang University of Science and Technology) ;
  • Kim, Kyong-Tai (Department of Life Science, Pohang University of Science and Technology)
  • Published : 1998.06.01
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Abstract

The effects of capsaicin on phospholipase (PLC)-induced capacitative $Ca^{2＋}$ entry (CCE) were investigated in PC12 cells. Capsaicin inhibited one of PLC-linked signal, extracellular ATP-induced norepinephrine secretion with a concentration range, 10-100 $\mu$M. Capsaicin did not inhibit the peak portion of extracellular ATP-mediated [Ca$^{2＋}$]i rise, but it recovered more rapidly to the normal level of [Ca$^{2+}$]i from the sustained [Ca$^{2+}$]i level.(omitted)ted)

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