Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)
- 1998.06a
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- Pages.19-19
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- 1998
Proline Effect on Structure and Activity of Antimicrobial Peptides
- Suh, Jeong-Yong (Department of Chemistry, KAIST) ;
- Park, Byong-Seok (Department of Chemistry, KAIST)
- Published : 1998.06.01
Abstract
Structure and activity of a helical antimicrobial peptide with a central proline (P14) and its alanine derivative (P14A) were investigated by NMR spectroscopy and biological assay. Chemical shift analysis showed that both of the peptides formed curved helix and P14 showed diminished stability near proline due to hindrance of hydrogen bonding by proline.(omitted)
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