한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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- Pages.196-196
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- 1998
Wogonin, a flavone from Scutellaria radix, inhibits nitric oxide production from RAW 264.7 cells
- Kim, Hee-Kee (College of Pharmacy, Kangwon National University) ;
- Cheun, Bong-Sun (College of Pharmacy, Kangwon National University) ;
- Kim, Young-Ha (College of Pharmacy, Kangwon National University) ;
- Kim, Sung-Yong (College of Pharmacy, Kangwon National University) ;
- Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University)
- 발행 : 1998.11.01
초록
Nitric oxide is involved in various physiological processes. Among isoforms of nitric oxide synthase, iNOS is partly responsible for inflammation and septic shock. During our continual search for anti-inflammatory flavonoids, we have found that flavonoids, especially flavones, possessed the inihibitory activity of NO production by iNOS from LPS-activated RAW 264.7 cell. In this study, flavonoids from Scutellaria radix were investigated for their inhibitory activity of nitric oxide production. It was found that wogonin, among tested flavonoids including baicalein, oroxylin A, skullcapflavone II, showed the strongest inhibition of nitric oxide production (IC
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