한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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- Pages.124-124
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- 1998
DA-9601, a Phytomedicine Derived from Artemisia asiatica, Blocks the Increased Susceptibility of Portal Hypertensive Gastropathy to Ethanol Damage
- Oh, Tae-Young (Research Lab., Dong-A Pharm. Co. Ltd.) ;
- Ahn, Byoung-Ok (Research Lab., Dong-A Pharm. Co. Ltd.) ;
- Ryu, Byung-Kweon (Research Lab., Dong-A Pharm. Co. Ltd.) ;
- Kim, Soon-Hoe (Research Lab., Dong-A Pharm. Co. Ltd.) ;
- Kim, Won-Bae (Research Lab., Dong-A Pharm. Co. Ltd.) ;
- Lee, Eun-Bang (Seoul National University, Natural Product Institute)
- 발행 : 1998.11.01
초록
Portal hypertensive gastropathy (PHG) is part of a complex syndrome which occurs as a complication of chronic liver disease and portal hypertension. The gastric mucosa in these patients shows typical congestion of ‘mosaic-like’ pattern and vulnerable to various noxious agents such as NSAIDs and ethanol. We previously reported that DA-9601, a quality-controlled extract from Artemisia asiatica, exhibits cytoprotection against various gastritis models. In the present study we investigated the effect of DA-9601 on ethanol-induced gastric damage in PHG rats. Experimental PHG was produced by CBD ligation in SD rats. DA-9601 was orally administered at a dose of 30 mg/kg or 100 mg/kg daily for 2 weeks.
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