Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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The Receptor-Ligand Interaction Revealed by a Homology Modelling of the Receptor Binding Domain of Human Thrombopoietin

  • Song, Jin-Soo (Protein Engineering Research Division, Korea Research Bioscience ＆ Biotechnology, KIST) ;
  • Park, Heung-Rok (Protein Engineering Research Division, Korea Research Bioscience ＆ Biotechnology, KIS) ;
  • Hong, Hyo-Jeong (Protein Engineering Research Division, Korea Research Bioscience ＆ Biotechnology, KIS) ;
  • Yu, Myeong-Hee (Protein Engineering Research Division, Korea Research Bioscience ＆ Biotechnology, KIS) ;
  • Ryu, Seong-Eon (Protein Engineering Research Division, Korea Research Bioscience ＆ Biotechnology, KIST)
  • Published : 1997.07.01
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Abstract

Platelet production in blood is regulated by a lineage specific humoral factor called thrombopoietin (TPO). The amino terminal domain of TPO (TPO-N) has a sequence homology to erythropoietin (EPO) and is responsible for the signal transduction mediated by the TPO receptor, c-mpl.(omitted)

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