Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
권호 표지

Human $\alpha_1$-Antitrypsin Variant with Enhanced Conformational Stability at the Cost of Activity

  • Seo, Eun-Joo (Division of Protein Engineering, Korea Research Institute of Bioscience and Biotechnology) ;
  • Hana Im (Division of Protein Engineering, Korea Research Institute of Bioscience and Biotechnology) ;
  • Yu, Myeong-Hee (Division of Protein Engineering, Korea Research Institute of Bioscience and Biotechnology)
  • Published : 1997.07.01
Download PDF
⟨ Previous Next ⟩

Abstract

Native strain of inhibitory SERPINS (Serine protease inhibitors) is thought to be used in the facile conformational switch to play biological regulation. Many heat stable variants of $\alpha$$_1$-antitrypsin, a prototype of inhibitory serpins, increased their stability by reducing the native strain.(omitted)

Keywords