Characterization of Single Channel Properties of Cardiac $Ca^{2+}$ Release Channel in Rats Treated with the Immunosuppressant Drug, Cyclosporin A

  • Lee, Eun-Hui (Dept. of Life Science, Kwangju Institute of Science and Technology (K-JIST)) ;
  • Park, Chul-Seung (Dept. of Life Science, Kwangju Institute of Science and Technology (K-JIST) ;
  • Kim, Do-Han (Dept. of Life Science, Kwangju Institute of Science and Technology (K-JIST))
  • Published : 1997.07.01

Abstract

Cyclosporin A (CsA) is widely used to suppress rejection in rcipients of solid organ or bone marrow transplants. A variety .of toxic side effects of this agent such as cardiotoxicity have been reported. However the underlying molecular mechanisms for the cardiotoxicity are not well resolved.(omitted)

Keywords