한국생물물리학회:학술대회논문집 (Proceedings of the Korean Biophysical Society Conference)

한국생물물리학회 (The Korean Biophysical Society)
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TWO TYPES OF $BA^{2+}$ BINDING SITES ON $K^+$ CHANNELS WITH DIFFERENT SENSITIVITY TO MEMBRANE SURFACE CHARGE

  • Park, Jin-Bong (Laboratory of Pharmacology, College of Veterinary Medicine, Seoul National University) ;
  • Ryu, Pan-Dong (Laboratory of Pharmacology, College of Veterinary Medicine, Seoul National University)
  • 발행 : 1996.07.01
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초록

Previously we showed that $Ba^{2+}$ block of large conductance $Ca^{2+}$-activated $K^{+}$ (BK) channel was larger in the planar lipid bilayer formed with negatively-charged phosphatidylserine (PS) than neutral phosphatidylethanolamine (PE). In this work, have studied the blocking effect of two $K^{+}$ channel blockers with different mechanisms of action, $Ba^{2+}$ and tetraethylammonium (TEA), on BK channels of rat skeletal muscle. (omitted)itted)

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