Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)
- 1996.04a
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- Pages.198-198
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- 1996
Mechanism of antiulceric effect of eupatilin, a biological active component of Arternisia extract
- Miwon Son (Research Laboratorie, Dong-A Pharm. Co. Ltd.) ;
- Oh, Tae-Young (Research Laboratorie, Dong-A Pharm. Co. Ltd.) ;
- Ryu, Byung-Kweon (Research Laboratorie, Dong-A Pharm. Co. Ltd.) ;
- Moohi Yoo (Research Laboratorie, Dong-A Pharm. Co. Ltd.) ;
- Kim, Won-Bae (Research Laboratorie, Dong-A Pharm. Co. Ltd.) ;
- Junnick Yang (Research Laboratorie, Dong-A Pharm. Co. Ltd.) ;
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Lee, Eun-Bang
(Natural Products Research Institute, Seoul National University)
- Published : 1996.04.01
Abstract
Eupatilin은 급성위궤양 모델인 HCl-EtOH model에서 0.3mg/kg에서 50% 억제하였으며 10mg/kg에서 95% 최대효과를 나타내었고, indomethacin model에서는 0.8mg/kg에서 50% 억제하였으며, 10mg/kg에서 97% 최대억제효과를 나타내었다. Cyclooxygenase-1의 활성은 1.7, 5.8
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