한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 1995년도 제3회 추계심포지움
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- Pages.49-57
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- 1995
CONFORMATIONALLY RESTRICTED DIACYLGLYCEROL ANALOGUES AS ULTRAPOTENT PROTEIN KINASE C LIGANDS - A. State in general terms the purpose and object of the research
- Lee, Jeewoo (Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University)
- 발행 : 1995.11.01
초록
Protein kinase C (PK-C) represents a central element transducing signals generated by a broad range of pathways which produce the lipid second messenger sn-1,2-diacylglycerol (DAG) directly or indirectly. Many dominant oncogenes have proven to function, at least in part, through this pathway Likewise, this pathway is involved in expression of other aspects of the transformed phenotype, such as tumor invasion or multidrug resistance. As expected from its broad role in cell signaling, PK-C Is also important in a range of other physiological and pathophysiological processes, including inflammation, differentiation, and nerve function.
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