The Acute Toxicity of Novel Platinum(II) Complexes in Mice

This study was conducted to examine novel Pt(II) complexes, (KHPC-002: [Pt(trans-1-dach) (DPPE)]. 2N0$_3$, KHPC-005: [Pt(cis-dach) (DPPE)] 2NO$_3$ and KHPC-006: [Pt(cis-dach) (DPPP)]. 2NO$_3$) for their acute toxicities. In male and female mice given a single intraperitoneal administration of KHPC-002, KHPC-005 and KHPC-006, we determined that LD$\_$50/ values of Pt(II) complexes were 295.5mg/kg(M), 350.4mg/kg(F) : KHPC-002, 596.5mg/kg(M), 674,8mg/kg(F): KHPC-005, 158.7mg/kg(M), 157.7mg/kg(F); KHPC-006, respectively. The signs of toxicity in mice observed fellowing the administration of these compounds included the followings: decreased mortor activity: abnormal gait: salviation, trasient decreased body weight. There were no treatment related specific changes in growth examination.