한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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- Pages.186-186
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- 1994
Development of screening systems for modulators on phospholipase-mediated signal transduction
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Lee, Young-Han-
(Department of Life Science, Pohang University of Science and Technology) ;
- Min, Do-Sik (Department of Life Science, Pohang University of Science and Technology) ;
- Kim, Jae-Ho- (Department of Life Science, Pohang University of Science and Technology) ;
- Suh, Pann-Ghill (Department of Life Science, Pohang University of Science and Technology) ;
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Ryu, Sung-Ho
(Department of Life Science, Pohang University of Science and Technology)
- 발행 : 1994.04.01
초록
Many agonists have been known to activate the hydrolysis of membrane phospholipids through the bindings with corresponding receptors on the various cells. Diacylglycerol and inositol 1,4,5-trisphosphate(IP3) generated by the action of phosphoinositide-specific phospholipase C (PI-PLC) are well known second messengers for the activation of protein kinase C and the mobilization of Ca2+ in many cells. Three types of PI-PLC isozyme (
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