Proceedings of the KIEE Conference (대한전기학회:학술대회논문집)

The Korean Institute of Electrical Engineers (대한전기학회)
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DESIGN OF A CHECK VALVE FOR FEEDING BIOLOGICAL CELLS ONE BY ONE

세포의 개별 공급을 위한 체크 밸브의 설계

  • Choi, Jung-Hoon (Department of Electrical Engineering, Seoul National University) ;
  • Lee, Sang-Wook (Department of Electrical Engineering, Seoul National University) ;
  • Kim, Yong-Kweon (Department of Electrical Engineering, Seoul National University)
  • Published : 1994.07.21
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Abstract

Feeding biological cells one by one is the key point in the manipulation of cells. The conventional valve systems have many difficulties in feeding cells one by one, because they shut the whole flow of fluids when they are closed and have possibilities of breaking the fragile cells. They need some other equipments for continuous supply of suspension and to protect the cells. We design a check valve for feeding biological cells one by one using polyimide all the silicon substrate. The cells are fed by hydraulic pressure through the isotropically etched cavity. When the suspension flows continuously along the channel the valve is bent by hydraulic pressure and a cell is fed to the outlet. We have studied a cell fusion device fabricated with polyimide and electroplating. If the designed check valve is located in front of the cell fusion device it is helpful to fuse two different kinds of cells.

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