Proceedings of the Ginseng society Conference (고려인삼학회:학술대회논문집)
- 1990.06a
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- Pages.196-200
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- 1990
Studies on the Hypoglycemic Effect of Ginseng Polypeptide
- Wang, B.X (Department of Pharmacology Academy of Tranditional Chinese Midicne and Materia Medica of Jilin Proveince) ;
- Yang, M. (Department of Pharmacology Academy of Tranditional Chinese Midicne and Materia Medica of Jilin Proveince) ;
- Jin, Y.L. (Department of Pharmacology Academy of Tranditional Chinese Midicne and Materia Medica of Jilin Proveince) ;
- Cui, X.Y. (Department of Pharmacology Academy of Tranditional Chinese Midicne and Materia Medica of Jilin Proveince) ;
- Wang, Y. (Department of Pharmacology Academy of Tranditional Chinese Midicne and Materia Medica of Jilin Proveince)
- Published : 1990.06.01
Abstract
the ginseng polypeptide (GPP) isolated from the root of Panax ginseng C.A. Meyer was demonstrated to decrease the levels of blood sugar and hepatic glycogen when injected intravenously to rats at a doses of 50-200mg/kg without affecting blood total lipid. When mice were injected subcutaneously daily at a dose of 50 and 100mg/kg for 7 successive days, GPP was also found to decreased blood sugar and hepatic glycoge. In addition, GPP was found to decrease various experimenta hyperglycemias induced by injection of adrenaline, glucose and alloxan. GPP exhibited inhibiting effect on the glycogen enhancement induced by glucose, but strengthening effect on the glycogen decrease induced by adrenaline. When the levels of blood total lipid and liver glycogen were increased by alloxan, GPP was shown to inhibit these changes except its lowering blood sugar. the toxicity of GPP is very low, its LD50 was found to be 1.62