Proceedings of the Ginseng society Conference (고려인삼학회:학술대회논문집)

The Korean Society of Ginseng (고려인삼학회)
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Biological Activities of Non-saponin Compounds Isolated from Korean Red Ginseng

  • Okuda, Hiromichi (2nd Department of Medical Biochemistry, School of Medicine, Ehime University) ;
  • Lee, Sung-Dong (2nd Department of Medical Biochemistry, School of Medicine, Ehime University) ;
  • Matsuura, Yukinaga (2nd Department of Medical Biochemistry, School of Medicine, Ehime University) ;
  • Zheng, Yinan (2nd Department of Medical Biochemistry, School of Medicine, Ehime University) ;
  • Sekiya, Keizo (2nd Department of Medical Biochemistry, School of Medicine, Ehime University) ;
  • Takeshi, Takaku (Center Research Laboratory, School of Medicine, Ehime Univ.) ;
  • Kameda, Kenji (Center Research Laboratory, School of Medicine, Ehime Univ.) ;
  • Hirose, Kumi (Insitute of Pharmaceutical Sci., School of Medicine, Hiroshima Univ.) ;
  • Ohtani, Kazuhiro (Insitute of Pharmaceutical Sci., School of Medicine, Hiroshima Univ.) ;
  • Tanaka, Osamu (Insitute of Pharmaceutical Sci., School of Medicine, Hiroshima Univ.) ;
  • Sakata, Toshiie (1st Dept. of Internal Medicine, School of Medicine, Kyushu Univ.)
  • Published : 1990.06.01
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Abstract

We have been isolating various physiologically active substances from non-saponin fraction of Korean Red Ginseng These are adenosine, gyro-glutamic acid, dencichine and acidic polysaccharide. Adenosine and gyro-glutamic acid are loom to inhibit epinephrine-induced lipolysis in fat cells and stimulate the insulin-mediated lipogenesis. In addition to these actions, adenosine was found to inhibit both norepinephrine- and histamine-induced aorta constriction, and pyre·glutamic acid inhibits angiotensin-converting enzyme. Dencichine stimulated histamine-induced aorta constriction. Finally, acidic polysaccharide was found to inhibit both lipolytic and anorexigenic actions of Toxohormone-L. Based on these experimental results, I presented a brief review on these compounds isolated from non- saponin fraction of Korea Red Ginseng. Keywords Panax ginseng, Korean red ginseng, adenosine, pyroglutamic acid, dencichine, acidic polysac- charide, lipolysis, lipogenesis, angiotensin-converting enzyme, toxohormone-L.

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