Proceedings of the KOSOMBE Conference (대한의용생체공학회:학술대회논문집)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Synthesis and Evaluation of Copoly(chitosan-g-L-lysine) for Wound Covering Material

Chitosan과 L-lysine의 공중합체로 부터 인공피부의 제조와 평가

  • Kim, K.Y. (Dept. of Industrial Chem., College of Eng., Hanyang Univ.) ;
  • Min, D.S. (Institute of Life Science, Sunkyong Industry) ;
  • Park, S.H. (Dept. of Industrial Chem., College of Eng., Hanyang Univ.) ;
  • Lee, S.Y. (Dept. of Industrial Chem., College of Eng., Hanyang Univ.) ;
  • Cho, Y.J. (Dept. of Microbiology, College of Medicine, Hanyang Univ.) ;
  • Chung, Y.H. (Dept. of Microbiology, College of Medicine, Hanyang Univ.) ;
  • Kim, J.M. (Dept. of Microbiology, College of Medicine, Hanyang Univ.)
  • 김계용 (한양대학교 공과대학 공업화학과) ;
  • 민동선 (선경인더스트리 생명과학연구소) ;
  • 박성호 (한양대학교 공과대학 공업화학과) ;
  • 이선용 (한양대학교 공과대학 공업화학과) ;
  • 조양자 (한양대학교 의과대학 미생물학교실) ;
  • 정용훈 (한양대학교 의과대학 미생물학교실) ;
  • 김정목 (한양대학교 의과대학 미생물학교실)
  • Published : 1989.05.26
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Abstract

The graft copolymer of chitosan with amino acid, L-lysine was synthesized by heterogeneous copolymerization and was evaluated as an artificial skin. The mechanical properties under dry and wet state, water content, water vapor transmittance rate and biodegradability were measured. The tensile strength and elongation under wet state ranged $0.3-0.5\;kg/mm^2$, 10-13%, respectively. Water vapor transmittance rate ranged $450-500\;g/m^2{\cdot}day$ like that of the normal skin. The weight loss of prepared membrane by protease IV was measured for the degree of biodegradation. The degree of biodegradation was around 15% and after 4 days it was slow. Biocompatibility was evaluated by studying the attachment of human fibroblast on the prepared membrane surface.

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