Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Antioxidative and Radical Scavenging Properties of the Constituents Isolated from Cosmos caudatus Kunth

  • Abas, Faridah (Laboratory of Phytomedicines, Institute of Bioscience) ;
  • Shaari, Khozirah (Laboratory of Phytomedicines, Institute of Bioscience) ;
  • Lajis, N.H. (Laboratory of Phytomedicines, Institute of Bioscience) ;
  • Israf, D.A. (Laboratory of Phytomedicines, Institute of Bioscience) ;
  • Kalsom, Y. Umi (Department of Biology University Putra Malaysia)
  • Published : 2003.12.01
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Abstract

A phytochemical investigation on the methanolic extract of Cosmos caudatus has led to the isolation of quercetin $3-O-{\beta}-D-arabinofuranoside$ (1), quercetin $3-O-{\beta}-D-rhamnoside$ (2), quercetin $3-O-{\alpha]-D-glucoside$ (3) and quercetin (4). These compounds were shown to be the antioxidative constituents of the plant when evaluated using the ferric thiocyanate (FTC) and thiobarbituric acid (TBA), and radical scavengers based on the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assays.

Keywords

References

  1. Burkill, I. H. A Dictionary of the Economic Products of the Malay Peninsular. Vols. 1 and 2. Ministry of Agriculture Cooperative, Kuala Lumpur, Malaysia (1966)
  2. Bors, W., Heller, W., and C. Michel., Flavonoid as antioxidants: Determination of radical scavenging efficiencies. Methods Enzymol. 186, 343-355 (1990) https://doi.org/10.1016/0076-6879(90)86128-I
  3. Braca, A., Chandra, S., Matteo, P., Ivano, M., and Jeannette, M., Antioxidant activity of flavonoids from Licania licaniaeflora. J. Ethnopharmacol. 79, 379-381 (2002) https://doi.org/10.1016/S0378-8741(01)00413-5
  4. Cotelle, N., Bernier, J. L., L. Catteau, J. P.,Pommery, P.,Wallet, J. C. and E. M. Gaydou., Antioxidant properties of hydroxyl-flavones. Free Radical Biology and Medicine. 20,35-43 (1996) https://doi.org/10.1016/0891-5849(95)02014-4
  5. Cuendet, M., Potterat, O., and K. Hostettmann., Flavonoids and Phenylpropanoid derivatives from Campanula barbata. Phytochem 56,631-636 (2001) https://doi.org/10.1016/S0031-9422(00)00423-4
  6. Fraisse, D., Hetz, A., Carnat, A., Carnat, A. P., and Lamaison, J. L., Quercetin 3-arabinopyranoside, a major flavonoid compound from Alchemilla xanthochlora. Fitoterapia 71, 463-464 (2001) https://doi.org/10.1016/S0367-326X(00)00145-3
  7. Fuzzati, N., Sutarjadi, Dyatmiko, W, Abdul Rahman and Hostettmann, K, Phenylpropane derivatives from roots of Cosmos caudatus. Phytochem. 39, 409-412 (1995) https://doi.org/10.1016/0031-9422(95)00031-2
  8. Harbone,J. B., Mabry, T. J., and Mabry, H., The Flavonoids. London: Chapman and Hall, 1975, pp. 64
  9. Ismail, S., Sayuran Tradisional Ulam dan Penyedap rasa. Universiti Kebangsaan Malaysia, Bangi, 2000
  10. Kikuzaki, H., and Nakatani, N., Antioxidant effects of some ginger constituents. J. Food Sci. 58, 1407-1410 (1993) https://doi.org/10.1111/j.1365-2621.1993.tb06194.x
  11. Lin, J. H., and Lin, Y. T., Flavonoids from the leaves of Loranthus kaoi (Choa) Kiu. J. Food and Drug Anal.. 7, 185-190 (1999)
  12. Markham, K. R., Temai, B., Stanley R, Geiger, H., and Mabry, T. J., Carbon-13 NMR studies of flavonoids-Ill. Tetrahedron 34, 1389-1397 (1978) https://doi.org/10.1016/0040-4020(78)88336-7
  13. Mathiesen, L., Malterud, K. E. and Sund, R. B., Hydrogen bond formation as basis for radical scavenging activity: A Structure-activity study of C-methylated dihydrochalcones from Myrica gale and structurally related acetophenones. Free Rad. Biol. and Med. 22,307-311 (1997) https://doi.org/10.1016/S0891-5849(96)00277-8
  14. Miller, B., Antioxidants Made Simple. Bruce Miller Ent. Inc., Petaling Jaya, 1995, pp. 131
  15. Norhanom, A. W., Ashril, Y., Mustafa, A. M., Anti-tumour Activity in Local Ulam. In Phytochemicals and Biopharmaceutins from the Malaysian Rain Forest, A. M. Ali et al. (ed.), 1999, pp. 135-141
  16. Peng, Z. F, Dieter, S., Alfred, B., Ramanathan, S., Goh, N. K, Chia, T. F, Tan, S. N., and Chia, L. S., Antioxidant flavonoids from leaves of Polygonum hydropiper L. Phytochem. 62, 219-228 (2003) https://doi.org/10.1016/S0031-9422(02)00504-6
  17. Pietta, P. G., Flavonoids as antioxidants. J. Nat. Prod. 63, 1035-1042 (2000) https://doi.org/10.1021/np9904509
  18. Pietta, P. G., Simonetti, P., and Mauri, P., Antioxidant activity of selected medicinal plants. J. Agric. Food Chem. 46, 4487-4490 (1998) https://doi.org/10.1021/jf980310p
  19. Wenkert, E., and Gottlieb, H. E., Carbon-13 nuclear magnetic resonance spectroscopy of flavonoid and isoflavonoid compounds. Phytochem. 16, 1811-1816 (1997) https://doi.org/10.1016/0031-9422(71)85095-1