The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Neuroprotective Effects of Scutellariae Radix on the Brain Ischemia induced by Four-Vessel Occlusion in Rats

황금(黃芩)의 4-VO로 유발한 흰쥐뇌허혈에 대한 신경방어효과

Lee Byung-Chul;Leem Kang-Hyun;Kim Young-Ock;Kim Sun-Yeou;Ahn Duk-Kyun;Park Ho-Koon;Kim Ho-Cheol
이병철;임강현;김영옥;김선려;안덕균;박호군;김호철

  • Published : 19990000

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Abstract

Scutellariae Radix(SR), the root of Scutellaria baicalensis $G_{EOROI}$, whose property, flavour and channel tropism is bitter in flavour, cold in property(寒), acting on the lung, gallbladder, stomach and large intestine channe1s(歸肺,膽,胃,大腸經), has the effects of clearing away heat and dampness(淸熱爆濕), purging fire, detoxicating(瀉火解毒), stopping bleeding(止血) and preventing miscarriage(安胎). This. drug is one of the popular drugs in traditional Korean medicine, which has been used to antipyretic, antibacterial, antitoxic and antihypersensitive effects. So this study was planned to check the neuroprotective effect of SR on the global ischemia induced by 4-vessel occlusion in Wister rats. and SR extract was lyophilized after extraction with $70\%$ methanol. We induced 4-vessel occlusion for 10 minutes and reperfused again. The number of CA1 pyramidal neurons were counted after 7 days of reperfusion under the cresyl violet staining. The results obtained that in 4-VO ischemia, SR showed significantly neuroprotective effects(l,000 and 500 mg/kg of SR extracts, p<0.05) compared with control group. Each neuroprotective ratio was about $27.4\;\%,\;23.2\;\%$ respectively. Consequently, Scutellariae Radix has neuroprotective effects on the global ischemia induced by 4-vessel occlusion in Wistar rats.

Keywords

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