The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

Neuroprotective Effects of Daeseungkitang on the Brain Ischemia induced by Four-Vessel Occlusion in Rats

대승기탕(大承氣湯)의 4-VO로 유한 흰쥐뇌허혈에 대한 신경방어효과

Kim Ho-Cheol;Ahn Duk-Kyun;Kim Young-Suk
김호철;안덕균;김영석

  • Published : 19990000

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Abstract

Daeseungkitang, the prescription which is composed of Rhei Radix, Magnoliae Cortex, Ponciri Fructus and Natrii Sulfas, has been used for the effect of expelling pathogenic heat and loosening the bowels, promoting the circulation of qi to purge accumulation in the bowels in Traditional Korean Medicine. This recipe is also one of the prescription to treat stroke in Kyung Hee University Oriental Medical Hospital. This study was planned to investigate the neuroprotective effect of Daeseungkitang on the globa1 ischemia induced by 4-vessel occlusion in Wister rats. Daeseungkitang extract was lyophilized with ethanol after reflux extraction with water. We induced 4-vessel occlusion for 10 minutes and reperfused again. The number of $CA_1$, pyramidal neurons were counted after 7 days of reperfusion under the cresyl violet staining. The result showed significant protective effects of samples compared with control group which was administrated with normal saline in the intraperitoneal injection of 1000 mg/kg and 500 mg/kg of Daeseungkitang extracts at 0, 2 and 6 hours after inducing cerebral ischemia.

Keywords

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