• Title, Summary, Keyword: thyroxine

Search Result 197, Processing Time 0.044 seconds

EFFECTS OF DIETARY THYROXINE ON GROWTH PERFORMANCE AND CARCASS QUALITY OF BROILERS FED DIFFERENT LEVELS OF DIETARY PROTEIN

  • Kim, J.W.;Lee, C.H.;Han, I.K.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • v.6 no.4
    • /
    • pp.527-539
    • /
    • 1993
  • To investigate the effects of crude protein and thyroxine on growth performance, nutrient utilizability, carcass composition, the content of total fat and cholesterol in leg muscle, breast muscle and liver, and caloric efficiency in broiler chicks. The experiment involved 3 levels of dietary crude protein (1-3 weeks: 20, 23, 26%; 4-6 weeks: 17, 20, 23%) and 3 levels of thyroxine (0.0, 1.5, 3.0 mg/kg). In the starting period (1-3 weeks), body weight gain of chicks fed diets containing 26% crude protein and 1.5 mg/kg thyroxine was higher than any other groups, and among thyroxine levels, 3.0 mg/kg thyroxine groups were lower. The best feed efficiency was obtained at 26% crude protein with no thyroxine supplemented or 1.5 mg/kg thyroxine supplemented groups. In the finishing period (4-6 weeks) the highest body weight gain was obtained at 23% crude protein with no thyroxine supplemented group. Feed intake of 17% crude protein with 1.5 mg/kg thyroxine supplemented group was higher than those of the other groups. It was found that the utilizability of crude protein in the starting period, showed the best utilizability at 20% crude protein with 1.5 mg/kg thyroxine group. Increasing crude protein level from 17 to 23%, utilizability of crude fat was decreased. The carcass composition was significantly (p<0.05) influenced by crude protein and thyroxine. Increasing thyroxine level from 0.0 to 3.0 mg/kg, crude protein content was increased whereas, crude fat content was decreased. Chicks fed diet containing 1.5 mg/kg thyroxine showed the lowest total fat content in liver tissue. In breast muscle, it was significantly (p<0.05) affected by crude protein and thyroxine. Present data revealed that the cholesterol content was increased for the chicks fed 3.0 mg/kg thyroxine. It the caloric efficiency, chicks fed a diet containing 20% crude protein with no thyroxine supplementation showed the highest caloric efficiency and the lowest efficiency was from 23% crude protein group with 1.5 mg/kg thyroxine. From this study it may be concluded that crude fat content of carcass could be successfully reduced by dietary supplementation of thyroxine, whereas crude protein content was increased.

Serum Thyroxine to Thyroxine-Binding Globulin Ratio in Pregnancy and Newborn (신부(娠婦)와 신생아(新生兒)에서 혈청(血淸)Thyroxine/Thyroxine-Binding Globulin 비(比))

  • Kim, Ji-Yeul
    • The Korean Journal of Nuclear Medicine
    • /
    • v.16 no.2
    • /
    • pp.59-61
    • /
    • 1982
  • To evaluate the diagnostic value of the ratio of serum tyroxine$(T_4)$/thyroxine-binding globulin (TBG) for the thyroid status in pregnancy and newborn serum thyroxine, TBG, triiodothyronine, and free thyroxine levels were radioimmunoassayed in normal pregnant women at each of the trimesters, and the calculated serum $T_4/TBG$ ratios were compared with other parameters such as $T_3/TBG$ ratio and free $T_4/TBG$ ratio and free $T_4/TBG$ ratio. Serum $T_4$ levels were elevated with the propotionate increase in TBG levels during pregnancy, leading to the nearly constant value of serum $T_4/TBG$ ratios as in normal non-pregnant controls. In contrast, serum $T_3/TBG$ and free $T_4/TBG$ ratios varied considerably during pregnancy. In newborn, $T_4$ levels were nearly not changed with compared non-pregnant control value and TBG levels were elevated. The results indicate that serum $T_4/TBG$ ratio is a better parameter than others in evaluating the thyroid status during pregnancy and but newborn is a no better.

  • PDF

Influence of Thyroxine on the Economic Parameters of the Bivoltine Silkworm, Bombyx Mori L.

  • Hugar, I.I.;Kaliwal, B.B.
    • Journal of Sericultural and Entomological Science
    • /
    • v.38 no.2
    • /
    • pp.130-137
    • /
    • 1996
  • Effect of topical application with 5, 10 and 15${\mu}$g/ml thyroxine on the pre-cocoon, cocoon, postcocoon and silk improvement were studied in bivoltine silkworm NB18 breed of B. mori L. Thyroxine was applied independently on alternate days to silkworm of IV and V instar larvae. The treatment of all different concentrations resulted in a significant increase in commercial characters like larval weight, silkgland weight, cocooning percentage, female cocoon weight and its shell weight and male cocoon shell weight and its ratio, cocoon dimension, length of the filament and its weight and oviposition. However, there was no significant change in larvel weight in 5${\mu}$g/ml treated group and larval duration was significantly decrease. But moth emergence percentage and hatching percentage did not show any significant change when compared with that of carrier control.

  • PDF

Influence of Thyroxine on the Hepatotoxicity of Carbon Tetrachloride ($CC1_4$의 간장독작용(肝臟毒作用)에 미치는 Thyroxine의 영향(影響))

  • Hong, Ki-Sung;Cheon, Yun-Sook
    • The Korean Journal of Pharmacology
    • /
    • v.16 no.2
    • /
    • pp.31-38
    • /
    • 1980
  • Calvert et al. formulated the hypothesis that carbon tetrachloride ($CCl_4$) acted on the central nervous system to produce and intensify sympathetic discharge which resulted in anoxic necrosis of the liver. Recknagel suggested that the essential feature of $CCl_4$ hepatotoxicity depended on the cleavage of it to $CCl_3$(free radical) and the peroxidative decomposition of cytoplasmic membrane structural lipids. And there are many reports which show the increase of adrenergic activity in hyperthyroidism. In this paper, the influence of thyroxine on the hepatotexicity of carbon tetrachloride was investigated in mice. The results obtained were summarized as follows; 1) Hepatic total lipid and lipid peroxide contents were slightly decreased by L-sodium thyroxine injection(4mg/kg/day for 4days or 6days), but hepatic glycogen content was significantly decreased. 2) Hepatic total lipid and lipid peroxide contents and serum lactic dehydrogenase activity were significantly increased by $CCl_4$ (4 ml/kg single dose or triple dose: 4ml/kg/day for 3days), but hepatic glycogen content was significantly decreased. 3) The increase of hepatic total lipid and lipid peroxide contents and serum lactic dehydrogenase activity induced by $CCl_4$ were significantly inhitited by the pretreatment of thyroxine. 4) The decrease of hepatic glycogen induced by $CCl_4$ was not affected by the pretreatment of thyroxine.

  • PDF

Vitamin D², Thyroxine, 및 Calcium gluconate가 백서악하선적출로 인한 혈중 Calcium농도변화에 미치는 영향

  • Cheong, Dong-Kyun;Park, No-Hee;Kim, Joong-KI
    • The Journal of the Korean dental association
    • /
    • v.12 no.12
    • /
    • pp.919-923
    • /
    • 1974
  • Serum calcium level was decreased by submaxillary gland removal in rate. To investigate the mechanisms involved in the above change, the authors examined the effects of thyroxine, vitamin D₂, and calcium gluconate, which influence the metabolisms of calcium and submaxillary gland, on the serum calcium level of the intact and submaxillary gland removal rats. The results were as follows: 1) Serum calcium level decreased by submaxillary gland removal. 2) Vitamin D₂, increased the serum calcium level significantly. 3) Thyroxine falied to recover the decreased serum calcium level induced by submaxillary gland removal to the control level. 4) In submaxillary gland removal rats, vitamin D₂ failed to increase the serum calcium level. 5) In thyroxine administered rats for 55 days, of which submaxillary glands were removed, vitamin D₂ failed to increase the serum calcium level. 6) The serum calcium level in intact rats was increased slightly, but increased significantly in submaxillary gland removal rats shortly after intravenous injection of calcium gluconate.

  • PDF

Studies on Histological Changes of Bursa of Fabricius in Chicken Treated with Thyroxine III. Electron Microscopic Observations on Bursa of Fabricius in Chicken Administered with Thyroxine or Propylthiouracil (갑상선(甲狀腺) 호르몬이 닭의 Fabricius 낭(囊)에 미치는 조직학적변화(組織學的變化)에 관(關)한 연구(硏究) III. Thyroxine 및 Propylthiouracil을 투여(投與)한 닭의 Fabricius 낭세포(囊細胞)에 대(對)한 전자현미경적관찰(電子顯微鏡的觀察))

  • Kim, Soon Bok;Lee, Cha Soo
    • Korean Journal of Veterinary Research
    • /
    • v.20 no.2
    • /
    • pp.105-112
    • /
    • 1980
  • The bursa of Fabricius from thyroxine-treated group showed increased number of large lymphocytes with well-developed cytoplasm, immunoblasts and proplasmacytes accompanied with active cell divisions. More prominent development of Golgi apparatus and mitochondria in the cytoplasm of the cells in the bursa from this group were also observed. The bursa of Fabricius from the propylthiouracil-treated group, however, distinctively revealed proliferation of fibroblasts in the interstitial tissues, decreased number of lymphocytes, and necrotic lymphocytes in the follicles.

  • PDF

Preliminary Studies on the Measurement of the Free Thyroxine in the Serum by the Radioimmunoassay (방사면역측정법(放射免疫測定法)에 의한 혈중(血中) 유리(遊離) Thyroxine 농도측정(濃度測定)에 대(對)한 기초적(基礎的) 검토(檢討))

  • Lee, Joon-Il
    • Journal of radiological science and technology
    • /
    • v.10 no.1
    • /
    • pp.85-90
    • /
    • 1987
  • Preliminary studies on the measurement of the free thyroxine in the serum with Amerlex $FT_{4}$ RIA kit were investigated using a tracer as $^{125}I-T_{4}$ derivative which is not almostly bound to thyroxine binding globulin, etc. The results are followed: 1. Linearity was tested on standards at various concentrations, and reproducibility and accuracy was excellent. 2. The antibody specificity is also excellent, and standard calibration curve of total $T_{4}$ was similar that of adding the TBG inhibitor. 3. Each value of $T_{4}$ in serum (the normal group, the hypothyroidism patients the pregnant women and the TBG dificiency patients) was not significant. As mentioned above, this method is more simple and rapid, compared to the other method.

  • PDF

Underlying mechanism of antioxidant action of Haejohwan in thyroxine-induced hyperthyroid rats (해조환(海藻丸)이 갑상선(甲狀腺) 기능항진증(機能亢進症)에서 항산화(抗酸化) 효과(效果)에 미치는 영향(影響))

  • Park, Jong-Hyuck;Yoon, Cheol-Ho;Seo, Un-Kyo;Kang, Jeong-Jun;Seo, Jong-Eun;Shin, Uk-Seob;Jeong, Ji-Cheon
    • The Journal of Internal Korean Medicine
    • /
    • v.21 no.3
    • /
    • pp.399-407
    • /
    • 2000
  • This study was carried out to examine if Haejohwan (HJ) inhibits oxidant-induced lipid peroxidation and therby produces protective effect against thyroxine-induced hyperthyroid rats. Triiodothyronine $(T_3)$, thyroxine $(T_4)$, lipid peroxidation, xathine oxidase activities and type conversion ratio were increased in thyroxine treated group. However, they were decreased in HJ extract's pre-applied group. Glutathione level, activities of glutathione peroxidase, glutathione Stransferase and glutathione reductase were decreased in thyroxine treated group. But, they were increased in HJ extract's pre-applied group. These results suggest that in thyroxine-induced hyperthyroid rats HJhas an increase in the activities of oxygen free radical scavenging enzymes and inhibition of xanthine oxidase activities, and prevents lipid peroxidation.

  • PDF